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Prof. Michael Michael: What is the Role of Patients in Trial Design and Efficacy

Prof. Michael is a Gastrointestinal and Neuroendocrine Medical Oncologist at the Peter MacCallum Cancer Centre, Melbourne.

In this presentation, recorded for INCA in 2022, Prof. Michael speaks about NET clinical trials that are practice-changing, and highlights the gaps in current NET research, as well as the role of patients in clinical trials design.

Highlights of the presentation:

  • “We need to better define the disease biology to help us to better select an individualized treatment, in other words precision medicine, in terms of what is being done with other malignancies”
  • “We need better biomarkers to predict disease behavior, and these need to be built in within all prospective research”
  • “We also need better studies to define the sequential therapy for all sub-classes of neuroendocrine tumors”
  • “Patients need to be involved in trial design to both refine and answer the right questions, to produce good quality results, and also to ensure that trial recruitment is completed”

Prof. Michael Michael Bio

Professor Michael is a Gastrointestinal and Neuroendocrine Oncologist, the Trial/Medical Lead of the Upper Gastrointestinal Service and Co-Chair of the Neuroendocrine Unit at Peter Mac, an ENETs Centre of Excellence. He graduated with honors in Medicine from Monash University, and undertook medical oncology training at Peter Mac. His major research interests are phase I/II trials of new drugs and chemoradiation regimens in gastrointestinal and neuroendocrine oncology; these have been translated into phase III studies through the cooperative trial groups. He also has a major interest in oncological clinical pharmacology and pharmacogenomics. He has assisted in setting up the first Australian standalone neuroendocrine tumor clinic, with a state-wide and national referral base. He is principal author or co-author of over 200 peer reviewed journal articles, invited reviews and chapters, over 170 conference abstracts as well as presentations at several local and international conferences.